Publish or perish ;-)

Some of our students (emphasized below) have managed to publish parts of the work they have done while in the program. Congratulations!

Selected Publications

2010

Decker JM, Wójtowicz AM, Bartsch JC, Liotta A, Braunewell KH, Heinemann U, Behrens CJ. C-type natriuretic peptide modulates bidirectional plasticity in hippocampal area CA1 in vitro. Neuroscience. 2010 May 7. [Epub ahead of print]. doi:10.1016/j.neuroscience.2010.04.064

2009

Klohs J, Baeva N, Steinbrink J, Bourayou R, Boettcher C, Royl G, Megow D, Dirnagl U, Priller J, Wunder A. In vivo near-infrared fluorescence imaging of matrix metalloproteinase activity after cerebral ischemia. J Cereb Blood Flow Metab. 2009 Jul;29(7):1284-92. doi:10.1038/jcbfm.2009.51

Klohs J, Steinbrink J, Bourayou R, Mueller S, Cordell R, Licha K, Schirner M, Dirnagl U, Lindauer U, Wunder A. Near-infrared fluorescence imaging with fluorescently labeled albumin: A novel method for non-invasive optical imaging of blood–brain barrier impairment after focal cerebral ischemia in mice. J Neurosci Methods. 2009 May 30;180(1):126-32. doi:10.1016/j.jneumeth.2009.03.002

Schmitt KR, Boato F, Diestel A, Hechler D, Kruglov A, Berger F, Hendrix S. Hypothermia-Induced Neurite Outgrowth is Mediated by Tumor Necrosis Factor-Alpha. Brain Pathol. 2009 Dec 8. doi:10.1111/j.1750-3639.2009.00358.x

Keller M, Mazuch J, Abraham U, Eom GD, Herzog ED, Volk HD, Kramer A, Maier B. A circadian clock in macrophages controls inflammatory immune responses. Proc. Natl. Acad. Sci. U.S.A. 2009 Dec 1. doi:10.1073/pnas.0906361106

Höltje M, Djalali S, Hofmann F, Münster-Wandowski A, Hendrix S, Boato F, Dreger SC, Grosse G, Henneberger C, Grantyn R, Just I, Ahnert-Hilger G. A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation. FASEB J. 2009 Apr; 23(4). doi:10.1096/fj.08-116855

Harmeier A, Wozny C, Rost BR, Munter LM, Hua H, Georgiev O, Beyermann M, Hildebrand PW, Weise C, Schaffner W, Schmitz D, Multhaup G. Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity. J. Neurosci. 2009 Jun 10; 29(23). doi:10.1523/JNEUROSCI.1336-09.2009

Markovic DS, Vinnakota K, Chirasani S, Synowitz M, Raguet H, Stock K, Sliwa M, Lehmann S, Kälin R, van Rooijen N, Holmbeck K, Heppner FL, Kiwit J, Matyash V, Lehnardt S, Kaminska B, Glass R, Kettenmann H. Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion. Proc. Natl. Acad. Sci. U.S.A. 2009 Jul 28; 106(30). doi:10.1073/pnas.0804273106

Freyer F, Aquino K, Robinson PA, Ritter P, Breakspear M. Bistability and non-Gaussian fluctuations in spontaneous cortical activity. J. Neurosci. 2009 Jul 1; 29(26). doi:10.1523/JNEUROSCI.0754-09.2009

Freyer F, Becker R, Anami K, Curio G, Villringer A, Ritter P. Ultrahigh-frequency EEG during fMRI: pushing the limits of imaging-artifact correction. Neuroimage 2009 Oct 15; 48(1). doi:10.1016/j.neuroimage.2009.06.022

Magno L, Catanzariti V, Nitsch R, Krude H, Naumann T. Ongoing expression of Nkx2.1 in the postnatal mouse forebrain: potential for understanding NKX2.1 haploinsufficiency in humans? Brain Res. 2009 Dec 22; 1304(). doi:10.1016/j.brainres.2009.09.050

Royl G, Balkaya M, Lehmann S, Lehnardt S, Stohlmann K, Lindauer U, Endres M, Dirnagl U, Meisel A. Effects of the PDE5-inhibitor vardenafil in a mouse stroke model. Brain Res. 2009 Apr 10; 1265(). doi:10.1016/j.brainres.2009.01.061

Ji S, Kronenberg G, Balkaya M, Färber K, Gertz K, Kettenmann H, Endres M. Acute neuroprotection by pioglitazone after mild brain ischemia without effect on long-term outcome. Exp. Neurol. 2009 Apr ; 216(2). doi:10.1016/j.expneurol.2008.12.007

Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M, Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Bräuer AU, Chun J, Ninnemann O, Schmitz D, Nitsch R. Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell 2009 Sep 18; 138(6). doi:10.1016/j.cell.2009.06.050

Neumann J, Bras J, Deas E, O'Sullivan SS, Parkkinen L, Lachmann RH, Li A, Holton J, Guerreiro R, Paudel R, Segarane B, Singleton A, Lees A, Hardy J, Houlden H, Revesz T, Wood NW. Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. Brain. 2009 Mar 13. doi:10.1093/brain/awp044

Wójtowicz AM, van den Boom L, Chakrabarty A, Maggio N, Haq RU, Behrens CJ, Heinemann U. Monoamines Block Kainate- and Carbachol-Iduced γ-Oscillations but Augment Stimulus-Induced γ-Oscillations in Rat Hippocampus In Vitro. Hippocampus. 2009 Jan 27. doi:10.1002/hipo.20508

Schmidt S, Vieweger A, Obst M, Mueller S, Gross V, Gutberlet M, Steinbrink J, Taubert S, Misselwitz B, Luedemann L, Spuler S. Dysferlin-deficient muscular dystrophy: gadofluorine M suitability at MR imaging in a mouse model. Radiology. 2009 Jan;250(1):87-94. doi:10.1148/radiol.2501080180

Siffrin V, Brandt AU, Radbruch H, Herz J, Boldakowa N, Leuenberger T, Werr J, Hahner A, Schulze-Topphoff U, Nitsch R, Zipp F. Differential immune cell dynamics in the CNS cause CD4+ T cell compartmentalization. Brain. 2009 Jan 29. doi:10.1093/brain/awn354

2008

Ritter P, Freyer F, Curio G, Villringer A. High-frequency (600 Hz) population spikes in human EEG delineate thalamic and cortical fMRI activation sites. Neuroimage 2008 Aug 15; 42(2). doi:10.1016/j.neuroimage.2008.05.026

Kronenberg G, Harms C, Sobol RW, Cardozo-Pelaez F, Linhart H, Winter B, Balkaya M, Gertz K, Gay SB, Cox D, Eckart S, Ahmadi M, Juckel G, Kempermann G, Hellweg R, Sohr R, Hörtnagl H, Wilson SH, Jaenisch R, Endres M. Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. J. Neurosci. 2008 Jul 9; 28(28). doi:10.1523/JNEUROSCI.0940-08.2008

Prinz V, Laufs U, Gertz K, Kronenberg G, Balkaya M, Leithner C, Lindauer U, Endres M. Intravenous rosuvastatin for acute stroke treatment: an animal study. Stroke 2008 Feb ; 39(2). doi:10.1161/STROKEAHA.107.492470

Richter JP, Behrens CJ, Chakrabarty A, Heinemann U. Effects of 4-aminopyridine on sharp wave-ripples in rat hippocampal slices. Neuroreport. 2008 Mar 5;19(4):491-6. doi: 10.1097/WNR.0b013e3282f79c61

Crossley NA, Sena E, Goehler J, Horn J, van der Worp B, Bath PM, Macleod M, Dirnagl U. Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke. 2008 Mar;39(3):929-34. doi:10.1161/STROKEAHA.107.498725

Bourayou R, Boeth H, Benav H, Betz T, Lindauer U, Nierhaus T, Klohs J, Wunder A, Dirnagl U, Steinbrink J. Fluorescence tomography technique optimized for noninvasive imaging of the mouse brain. J Biomed Opt. 2008 Jul-Aug;13(4):041311 doi:10.1117/1.2968262

Zimmerman G, Njunting M, Ivens S, Tolner EA, Behrens CJ, Gross M, Soreq H, Heinemann U, Friedman A. Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. Eur J Neurosci. 2008 Feb;27(4):965-75. doi:10.1111/j.1460-9568.2008.06070.x

Bourayou R, Boeth H, Benav H, Betz T, Lindauer U, Nierhaus T, Klohs J, Wunder A, Dirnagl U, Steinbrink J. Fluorescence tomography technique optimized for noninvasive imaging of the mouse brain. J Biomed Opt. 2008 Jul-Aug;13(4):041311. doi:10.1117/1.2968262

Wunder A, Klohs J, Dirnagl U. Non-invasive visualization of CNS inflammation with nuclear and optical imaging. Neuroscience. 2008 Oct 10. doi:10.1016/j.neuroscience.2008.10.005

Klohs J, Gräfe M, Graf K, Steinbrink J, Dietrich T, Stibenz D, Bahmani P, Kronenberg G, Harms C, Endres M, Lindauer U, Greger K, Stelzer EH, Dirnagl U, Wunder A. In vivo imaging of the inflammatory receptor CD40 after cerebral ischemia using a fluorescent antibody. Stroke. 2008 Oct;39(10):2845-52. doi:10.1161/STROKEAHA.107.509844

Steinbrink J, Liebert A, Wabnitz H, Macdonald R, Obrig H, Wunder A, Bourayou R, Betz T, Klohs J, Lindauer U, Dirnagl U, Villringer A. Towards noninvasive molecular fluorescence imaging of the human brain. Neurodegener Dis. 2008;5(5):296-303. doi:10.1159/000135614

Wunder A, Klohs J. Optical imaging of vascular pathophysiology. Basic Res Cardiol. 2008 Mar;103(2):182-90. doi:10.1007/s00395-008-0712-5

Klohs J, Wunder A, Licha K. Near-infrared fluorescent probes for imaging vascular pathophysiology. Basic Res Cardiol. 2008 Mar;103(2):144-51. doi:10.1007/s00395-008-0702-7

Becker R, Ritter P, Villringer A. Influence of ongoing alpha rhythm on the visual evoked potential. Neuroimage. 2008 Jan 15;39(2):707-16. doi:10.1016/j.neuroimage.2007.09.016

Yildirim F, Gertz K, Kronenberg G, Harms C, Fink KB, Meisel A, Endres M. Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury. Exp Neurol. 2008 Apr;210(2):531-42. doi:10.1016/j.expneurol.2007.11.031

Harnack D, Meissner W, Jira JA, Winter C, Morgenstern R, Kupsch A. Placebo-controlled chronic high-frequency stimulation of the subthalamic nucleus preserves dopaminergic nigral neurons in a rat model of progressive Parkinsonism. Exp Neurol. 2008 Mar;210(1):257-60. doi:10.1016/j.expneurol.2007.10.002

2007

Motazacker MM, Rost BR, Hucho T, Garshasbi M, Kahrizi K, Ullmann R, Abedini SS, Nieh SE, Amini SH, Goswami C, Tzschach A, Jensen LR, Schmitz D, Ropers HH, Najmabadi H, Kuss AW. A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation. Am. J. Hum. Genet. 2007 Oct ; 81(4). doi:10.1086/521275

Zurborg S, Yurgionas B, Jira JA, Caspani O, Heppenstall PA. Direct Activation of the Ion Channel TRPA1 by Ca2+. Nat Neurosci. 2007 Mar;10(3):277-9. doi:10.1038/nn1843

Ritter P, Becker R, Graefe C, Villringer A. Evaluating gradient artifact correction of EEG data acquired simultaneously with fMRI. Magn Reson Imaging. 2007 Jul;25(6):923-32. doi:10.1016/j.mri.2007.03.005

Mutlu L, Brandt C, Kwidzinski E, Sawitzki B, Gimsa U, Mahlo J, Aktas O, Nitsch R, van Zwam M, Laman JD, Bechmann I. Tolerogenic effect of fiber tract injury: reduced EAE severity following entorhinal cortex lesion. Exp Brain Res. 2007 Apr;178(4):542-53. doi:10.1007/s00221-006-0758-2

Waiczies S, Bendix I, Prozorovski T, Ratner M, Nazarenko I, Pfueller CF, Brandt AU, Herz J, Brocke S, Ullrich O, Zipp F. Geranylgeranylation but not GTP loading determines rho migratory function in T cells. J Immunol. 2007 Nov 1;179(9):6024-32.

Boehmerle W, Zhang K, Sivula M, Heidrich FM, Lee Y, Jordt SE, Ehrlich BE. Chronic exposure to paclitaxel diminishes phosphoinositide signaling by calpain-mediated neuronal calcium sensor-1 degradation. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11103-8. doi:10.1073/pnas.0701546104

2006

Klohs J, Steinbrink J, Nierhaus T, Bourayou R, Lindauer U, Bahmani P, Dirnagl U, Wunder A. Noninvasive near-infrared imaging of fluorochromes within the brain of live mice: an in vivo phantom study. Mol Imaging. 2006 Jul;5(3):180-7.

Jandová K, Päsler D, Antonio LL, Raue C, Ji S, Njunting M, Kann O, Kovács R, Meencke HJ, Cavalheiro EA, Heinemann U, Gabriel S, Lehmann TN. Carbamazepine-resistance in the epileptic dentate gyrus of human hippocampal slices. Brain. 2006 Dec;129(Pt 12):3290-306. doi:10.1093/brain/awl218

Stroh A, Zimmer C, Werner N, Gertz K, Weir K, Kronenberg G, Steinbrink J, Mueller S, Sieland K, Dirnagl U, Nickenig G, Endres M. Tracking of systemically administered mononuclear cells in the ischemic brain by high-field magnetic resonance imaging. Neuroimage. 2006 Nov 15;33(3):886-97. doi:10.1016/j.neuroimage.2006.07.009

Meisel A, Harms C, Yildirim F, Bösel J, Kronenberg G, Harms U, Fink KB, Endres M. Inhibition of histone deacetylation protects wild-type but not gelsolin-deficient neurons from oxygen/glucose deprivation. J Neurochem. 2006 Aug;98(4):1019-31. doi:10.1111/j.1471-4159.2006.04016.x

Boehmerle W, Splittgerber U, Lazarus MB, McKenzie KM, Johnston DG, Austin DJ, Ehrlich BE. Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism.. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18356-61. doi:10.1073/pnas.0607240103

2005

Winter B, Juckel G, Viktorov I, Katchanov J, Gietz A, Sohr R, Balkaya M, Hörtnagl H, Endres M. Anxious and hyperactive phenotype following brief ischemic episodes in mice. Biol. Psychiatry 2005 May 15; 57(10). doi:10.1016/j.biopsych.2005.02.010

Kann O, Kovács R, Njunting M, Behrens CJ, Otáhal J, Lehmann TN, Gabriel S, Heinemann U. Metabolic dysfunction during neuronal activation in the ex vivo hippocampus from chronic epileptic rats and humans. Brain. 2005 Oct;128(Pt 10):2396-407. doi:10.1093/brain/awh568

Wenzel K, Zabojszcza J, Carl M, Taubert S, Lass A, Harris CL, Ho M, Schulz H, Hummel O, Hubner N, Osterziel KJ, Spuler S. Increased susceptibility to complement attack due to down-regulation of decay-accelerating factor/CD55 in dysferlin-deficient muscular dystrophy.. J Immunol. 2005 Nov 1;175(9):6219-25.

Becker R, Ritter P, Moosmann M, Villringer A. Visual evoked potentials recovered from fMRI scan periods. Hum Brain Mapp. 2005 Nov;26(3):221-30. doi:10.1002/hbm.20152

Kwidzinski E, Bunse J, Aktas O, Richter D, Mutlu L, Zipp F, Nitsch R, Bechmann I. Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation. FASEB J. 2005 Aug;19(10):1347-9. doi:10.1096/fj.04-3228fje

2004

Gabriel S, Njunting M, Pomper JK, Merschhemke M, Sanabria ER, Eilers A, Kivi A, Zeller M, Meencke HJ, Cavalheiro EA, Heinemann U, Lehmann TN. Stimulus and potassium-induced epileptiform activity in the human dentate gyrus from patients with and without hippocampal sclerosis. J Neurosci. 2004 Nov 17;24(46):10416-30. doi:10.1523/JNEUROSCI.2074-04.2004

2003

Lehmann TN, Gabriel S, Eilers A, Njunting M, Kovacs R, Schulze K, Lanksch WR, Heinemann U. Fluorescent tracer in pilocarpine-treated rats shows widespread aberrant hippocampal neuronal connectivity.. Eur J Neurosci. 2001 Jul;14(1):83-95. doi:10.1046/j.0953-816x.2001.01632.x